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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA2 All Species: 13.64
Human Site: T1173 Identified Species: 25
UniProt: Q9BZC7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BZC7 NP_001597 2435 269873 T1173 L K Y K P G R T I L L S T H H
Chimpanzee Pan troglodytes XP_001152577 2346 264166 A1111 K G K S Q E E A Q L E M E A M
Rhesus Macaque Macaca mulatta XP_001117819 2476 273629 T1200 L K Y K P G R T I L L S T H H
Dog Lupus familis XP_537788 2395 264756 H1163 V S Q F I R K H V A S C L L V
Cat Felis silvestris
Mouse Mus musculus P41234 2434 270490 T1173 L K Y K P G R T I L L S T H H
Rat Rattus norvegicus Q9ESR9 2434 270910 T1173 L K Y K P G R T I L L S T H H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 R1074 V D P Y S R R R I W E L L L K
Chicken Gallus gallus XP_422330 2276 256293 L1084 G E A K V V V L D E P T S G V
Frog Xenopus laevis NP_001089022 2363 267334 E1115 R Q V E V M L E D I G I P H K
Zebra Danio Brachydanio rerio NP_001139161 2268 254351 D1076 Y A R R G I W D L L L K Y R Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 P512 D M E I Q M N P M A S T S L N
Sea Urchin Strong. purpuratus XP_798273 1913 213253 P721 M S S S D D E P G F E P E P V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 K689 R A L S G G M K R K L S L G I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.1 96 82.2 N.A. 91 92.9 N.A. 39.1 35.7 36.5 37.7 N.A. N.A. N.A. 23.7 41.7
Protein Similarity: 100 52 96.6 86.1 N.A. 93.2 94.9 N.A. 55.7 53.5 54.7 54.5 N.A. N.A. N.A. 39 54.4
P-Site Identity: 100 6.6 100 0 N.A. 100 100 N.A. 13.3 6.6 6.6 13.3 N.A. N.A. N.A. 0 0
P-Site Similarity: 100 6.6 100 20 N.A. 100 100 N.A. 20 26.6 26.6 26.6 N.A. N.A. N.A. 26.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. 26.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 8 0 0 0 0 8 0 16 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 8 8 0 0 8 8 0 8 16 0 0 0 0 0 0 % D
% Glu: 0 8 8 8 0 8 16 8 0 8 24 0 16 0 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 0 % F
% Gly: 8 8 0 0 16 39 0 0 8 0 8 0 0 16 0 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 39 31 % H
% Ile: 0 0 0 8 8 8 0 0 39 8 0 8 0 0 8 % I
% Lys: 8 31 8 39 0 0 8 8 0 8 0 8 0 0 16 % K
% Leu: 31 0 8 0 0 0 8 8 8 47 47 8 24 24 0 % L
% Met: 8 8 0 0 0 16 8 0 8 0 0 8 0 0 8 % M
% Asn: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % N
% Pro: 0 0 8 0 31 0 0 16 0 0 8 8 8 8 0 % P
% Gln: 0 8 8 0 16 0 0 0 8 0 0 0 0 0 8 % Q
% Arg: 16 0 8 8 0 16 39 8 8 0 0 0 0 8 0 % R
% Ser: 0 16 8 24 8 0 0 0 0 0 16 39 16 0 0 % S
% Thr: 0 0 0 0 0 0 0 31 0 0 0 16 31 0 0 % T
% Val: 16 0 8 0 16 8 8 0 8 0 0 0 0 0 24 % V
% Trp: 0 0 0 0 0 0 8 0 0 8 0 0 0 0 0 % W
% Tyr: 8 0 31 8 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _